Prostanin

Relieves urinary symptoms of an aging prostate
  • Substances’ effect enhanced by multilayer coating
  • The most beneficial ingredients for the prostate gland
  • Unique synergistic combination of botanicals & nutrients includes silymarin & betasitosterols
  • Prevention & sollution of prostate problems in men
Dietary suplement for men
Prostanin package
1
Capsule
a day
30
Vegetarian
capsules
30
Vegetarian
capsules
1
Capsule
a day
Prostanin package
Vegicaps

Prostanin

produced by

Guergi

Effects

<
  • 1 General Effects
  • 2 Silymarin
  • 3 Selenium
  • 4 Phytosterol
  • 5 Zinc
>
  • Prostanin® is an original preparation for prostate care. Its composition is designed so that each of its components has a beneficial effect on the prostate through a different mechanism, resulting in a synergic and therefore multiplying effect.

    One of the most notable substances of this type is the alkaloid piperine, obtained from black pepper seeds. According to the latest findings, piperine blocks the activity of enzymes (CYP3A4, P-glycoprotein and others) that play an important role in metabolism and transporting a wide variety of metabolites, including biologically active substances used in the form of medicaments or food supplements (Bhardwaj et al. 2002, Srinivasan 2007, Atal et al. 1985), thus improving their bioavailability (Reen et al. 1993). That makes it possible to improve the bioavailability of a number of vitamins, including vitamin D, minerals, including selenium and zinc, and also silymarin (Vasavirama K., Mahesh Upender 2014, Sabinsa 2014).

  • According to the latest scientific research, besides a beneficial effect on the liver, silymarin, a substance contained in extract of milk thistle, is also a promising resource for complementary treatment of prostate cancer. According to numerous studies, silymarin and the substance silybin it contains inhibit the growth of prostate cancer cells. These substances have pro-apoptotic effects (they induce the death of cancer cells) and are therefore already used in complementary treatment for prostate cancer (Gažák et al. 2007, Singh et al. 2008). In addition to inhibiting cancer cell growth, silybin prevents the cells’ mobility and migration and reduces their ability to attack healthy prostate cells (Wu et al. 2010). The combination of silymarin and selenium also has positive effects (Vidlar et al., 2010, Vostalová et al. 2013).

  • Selenium promotes the protection of cells against oxidative stress, thus reducing the risk of illnesses. A combination of silymarin and selenium has proven effective in countering the progression of prostate cancer (Vidlar et a. 2010) and in improving the condition of the lower urinary tract and the content of prostatic specific antigen (PSA) in men with benign hyperplasia of the prostate gland (Vostalová et al. 2013).

  • Phytosterol from soya, known as beta-Sitosterol, has a beneficial effect on the urinary tract in the event of benign prostatic hyperplasia (BPH). According to a study done on 130 men with BPH, using beta-Sitosterol for six months improved the patients’ IPSS (International Prostate Symptom Score), which characterises the functioning of the urinary system (e.g. urine flow, ability to completely empty the bladder et al.) and improved their quality of life (Klippel et a. 1997). The study’s authors deduce from the results that beta-Sitosterol is an efficacious option in the treatment of BPH, and a follow- up study on 519 individuals responding by text message confirmed this finding (Wilt et al. 1999). A lot of research into phytosterols and their use against prostate cancer is also taking place, as in cancer cells they inhibit cell division and induce apoptosis, i.e. the death of the cancer cells (von Holtz et al. 1998).

  • Zinc is fairly abundant in the prostate gland – it is a key material for prostate health, even though its function in the prostate is not yet fully understood (Zaichick et al. 1997). It is a known fact, however, that a reduced zinc level in the prostate means an increased risk of prostate cancer (Leitzmann et al. 2003). Zinc has the ability to inhibit cancer cell growth and prevent cancer cells invading the prostate gland (Liang et al. 1999, Feng et al. 2000). It is thought that increasing the intake of zinc into the body can reduce the propensity to prostate cancer by protecting against oxidative damage of prostate cells, by boosting the “repair” of damaged DNA and limiting uncontrolled cell division (Ho, Yan 2005). Similarly, a link has been found between reduced zinc levels in prostate tissue and the development of BPH (Christudoss et al. 2011).

    As with zinc, a lower serum vitamin D level is linked to an increased risk of prostate cancer. An extensive study involving 19,000 men showed that a serum vitamin D level lower than 16 ng/ml resulted in a 70% greater risk of prostate cancer than when the levels are above that value (Ahonen et al. 2000). More than 1,000 studies today support the existence of a link between a sufficient intake (or synthesis) of vitamin D and reduced incidence of cancer of various organs, including the prostate gland (Garland et al. 2006). The link between reduced vitamin D levels and the incidence of BPH has also been reliably described. Vitamin D’s effect is attributed to its immunomodulation capability.

<
<

It has been known for several decades that some natural substances are capable of increasing the bioavailability of both natural and synthetic biologically active substances.

Composition of prostanin

Unique synergistic combination
of botanicals & combination

1 capsule contains

mg / capsule

% RDD*

Silymarin

250.000

not defined

Phytosterols from soya

12.500

not defined

Zinc

10.000

100

Cholecalciferol (vitamin D3)

0.025

500

Selenium

0.055

100

Microcrystalline celullose**

14.820

not defined

Coating mixture: hydroxypropyl methylcellulose, talcum, piperine, curcumin.
* recommended daily dose
** additive

Progresive technologies

PROSTANIN®, a brand new and original preparation made by Guergi,
is the absolute leader among food supplements intended for prostate care.

In line with the latest scientific research, the preparation contains the most efficacious ingredients that have a beneficial effect on the prostate gland. What is more, the production process makes use of state-of-theart technologies guaranteeing that the organism makes maximum use of the ingredients. As a result, Prostanin® is faster-acting and fundamentally more efficacious than comparable products, while also using fewer raw materials.

Micronization method

More effective absorbtion
of active ingredients into the body

Micronization is a modern method making it possible to achieve the smallest possible dimensions of nutrients and other substances taken orally. Measuring a few micrometres, micronized particles have a much greater surface area than normally used ingredients. This makes the active ingredient more accessible for the organism – the micronized substance dissolves more easily and quickly in the body’s liquids, which enhances the biological effect of the nutrient.

Multilayer coating

Pellets release active ingredients
more effectively and gradually

In multilayer coating, pellets with active ingredients can be coated with different layers that allow the substances to be released gradually. That makes it possible to modify the subsequent release and biological effects of these components. Prostanin pellets are coated with a layer of piperine, an extract of black pepper, which is released from the coating before the active ingredients inside the pellet. This preincubation with piperine significantly increases the bioavailability of the active ingredients.

Vegetarian capsules

Vegicaps —
no animal origin of capsules

Unlike ordinary gelatin capsules made from the bones, cartilage and skin of animals, vegetarian capsules are of purely plant origin. That makes them suitable for vegetarians. They are also halal certified. Vegetarian capsules made from cellulose fibers are more stable, even in more extreme climatic conditions, which prolongs the lifespan of the active substances contained in them. Prostanin comes in capsules produced from a plant material (HPMC – hydroxypropylmethylcelullose), making it suitable for vegetarians.

References

Ahonen M.H., Tenkanen L., Teppo L., Hakama M., Tuohimaa P (2000). Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels. Cancer Causes Control. 11(9): 847–852.

Atal CK, Dubey RK, Singh J (January 1985). Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

J. Pharmacol. Exp. Ther. 232 (1): 258–62. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF (2002).

Ahonen M.H., Tenkanen L., Teppo L., Hakama M., Tuohimaa P (2000). Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels. Cancer Causes Control. 11(9): 847–852.

Atal CK, Dubey RK, Singh J (January 1985). Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

J. Pharmacol. Exp. Ther. 232 (1): 258–62. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF (2002).